You should include any course taken during 9th-12th grade that will appear on your transcript! That includes absolutely any subject, though only core classes will contribute to your RaiseMe GPA.
If you took high school classes in middle school, you should not include them in your Portfolio even if they are eventually going to be on your transcript. If you are graduating a year early, read more here.
During your Senior year, you can add courses to your Portfolio at any time. If you add your courses in before receiving a grade, please make sure to go back later in the year to add your official grades. Please keep in mind that once the earning deadline passes, RaiseMe is not able to submit any more information to the college. For example, if a college you're following has an earning deadline of 12/15, any courses or achievements added after this date will not count towards earnings for that particular college.